I use this daily with my Tretinonin and it has made an enormous difference in reducing redness and irritation. I use it in my nighttime routine, just before applying Tretininon, and then immediately after. The redness is completely gone!! I've used Tretinoin for decades and also Matrixyl Synth 6. But not sandwiched like this this. I am astonished beyond measure that it buffered the negative effects and is allowing me to use it consistently now. I'll never not use this together again!! It is astounding!!!!