Timeless Skin Care Coenzyme Q10 Serum is a multi-tasking anti-aging serum built on three actives in one lightweight, fragrance-free formula: 2% Coenzyme Q10 (Ubiquinone) for antioxidant protection, 8% Matrixyl® 3000 peptides to support collagen, and 1% Hyaluronic Acid for hydration, plus Vitamin E. It is priced at $28.95 for 1 oz ($17.37 with code FALL40, or $23.16 with Subscribe & Save 20%), and is also available in 4 oz. In a third-party clinical trial of 20 participants ages 32–64, after 3 weeks of use 100% agreed skin felt more moisturized and regenerated, firmness and elasticity looked improved, and wrinkles looked visibly reduced. The formula is paraben free, sulfate free, dye free, vegan, cruelty free, and made in small batches in the USA, and it holds a 4.9/5 star rating from 3,243 reviews.
Best for
All skin types, especially anyone with visible signs of aging, wrinkles, dullness, hyperpigmentation, or discoloration
Shoppers who want an antioxidant, peptide, and hydration step combined in a single serum instead of stacking several products
Fragrance-avoidant and sensitive-skin routines — the formula has no added fragrance, though patch testing is recommended for highly reactive skin
Mature skin, which naturally produces less Coenzyme Q10 over time
Anyone looking for a peptide-based option described on the page as a safe, effective alternative to Retinoids and Retinols
Not recommended for anyone with the vitiligo skin condition, and not for direct application to the under-eye area
How it compares
Unlike a single-ingredient CoQ10 serum, Timeless combines 2% CoQ10, 8% Matrixyl® 3000, 1% Hyaluronic Acid, and Vitamin E in one clean, fragrance-free formula, made in small batches in the USA for potency and freshness. Compared with the brand's Matrixyl® 3000 Serum — a polypeptide-only formulation for those who already have an antioxidant or cannot use Ubiquinone — this serum pairs the peptide with a powerful antioxidant, so you can alternate the two or choose whichever fits your routine. The page also positions Matrixyl® 3000 as a safe and effective alternative to Retinoids, and notes this serum can be layered alongside retinol or vitamin C rather than replacing them.
Frequently asked questions
What is the shelf life of the Coenzyme Q10 Serum? For best results, we recommend using your Coenzyme Q10 Serum within 24 months of receipt. The period after opening symbol is provided on the product box, and use upon receipt and refrigeration is suggested to assist with the shelf life of the product.
How long does the Coenzyme Q10 Serum last with daily use? With the suggested daily use amount of 2-3 drops, a 1oz bottle typically lasts about 1 month.
Can I use the Coenzyme Q10 Serum under the eyes? We do not recommend applying it directly to the under-eye area. The skin around the eyes is very delicate, so we recommend products specifically formulated for the eye area instead.
How do I layer the Coenzyme Q10 Serum with my other Timeless products? As a general rule, apply products from thinnest to thickest. For further assistance, email consult@timelessha.com.
Is the Coenzyme Q10 Serum safe for use during pregnancy? Yes, it is suitable for use during pregnancy and breastfeeding when used as directed. For external use on face and neck only; avoid eyes and chest/nipple area, discontinue if irritation occurs, and store in a cool, dry place away from sunlight.
What is the difference between the Coenzyme Q10 Serum & Matrixyl® 3000 Serum? Coenzyme Q10 is a powerful antioxidant combined with an anti-aging polypeptide, while Matrixyl 3000 is a polypeptide-only formulation for those who have another antioxidant choice or cannot use Ubiquinone. Alternate the two serums or choose the one best suited to your needs.
Why is the Coenzyme Q10 Serum not recommended for people with vitiligo? Coenzyme Q10 may support skin-brightening effects in some users, and because vitiligo involves areas of hypopigmentation, uneven tone may become more noticeable. If you have vitiligo, consult your dermatologist before adding it to your routine.
How should I apply the Coenzyme Q10 Serum? Apply 2-3 drops onto fingers and spread evenly over the desired area, waiting until fully absorbed before the next step in your routine. Use daily, AM or PM (recommended).
What are the key ingredients in Coenzyme Q10 Serum? Water, Matrixyl® 3000, Ubiquinone (Coenzyme Q10), Aloe Barbadensis, Glycerin, Hyaluronic Acid, Vitamin E, Benzyl Alcohol, and Dehydroacetic Acid.
What are the benefits of Coenzyme Q10 Serum? Benefits include powerful antioxidant defense, minimizing visible signs of aging, helping restore firmness and texture, repairing damaged skin, protecting skin cells against free radical damage, and stimulating production of healthy skin cells.
What clinical results have been demonstrated for this serum? Based on a third-party clinical trial of 20 participants ages 32-64, after 3 weeks of use: 100% agreed skin feels more moisturized and regenerated, 100% agreed firmness and elasticity is improved, and 100% agreed wrinkles are visibly reduced.
Can I use Coenzyme Q10 Serum every day? Yes. It is gentle enough for daily use, morning or evening after cleansing, and consistent use helps maintain hydration while the Matrixyl® 3000 peptides improve the appearance of texture and firmness over time.
Should I use Coenzyme Q10 Serum in the morning or at night? Either. Its antioxidant, hydrating, peptide-rich formula supports healthy-looking skin throughout the day and overnight.
Can I use Coenzyme Q10 Serum with Vitamin C? Yes. Coenzyme Q10 pairs well with Vitamin C — together they create a comprehensive antioxidant skincare routine.
Can I use Coenzyme Q10 Serum with retinol? Yes. It complements retinol by helping replenish hydration and providing antioxidant support; apply it before your moisturizer, and if you use retinol at night, follow your preferred layering routine.
Is Timeless Coenzyme Q10 Serum good for mature skin? Yes. Mature skin naturally produces less Coenzyme Q10 over time, and this serum replenishes topical antioxidant support while the peptides and Hyaluronic Acid help improve the appearance of firmness, hydration, and visible wrinkles.
Does Coenzyme Q10 help with wrinkles? Coenzyme Q10 helps reduce oxidative stress that contributes to visible skin aging. Combined with Matrixyl® 3000 peptides, it helps soften the appearance of fine lines and wrinkles while promoting smoother, healthier-looking skin.
Can I use Coenzyme Q10 Serum with Hyaluronic Acid? Yes — the serum already contains Hyaluronic Acid, which helps attract and retain moisture for hydrated, plumper-looking skin.
Is Timeless Coenzyme Q10 Serum fragrance-free? Yes. It is formulated without added fragrance, making it a great option for those who prefer fragrance-free skincare.
How long does it take to see results? Hydration can often be noticed after the first few applications; improvements in the appearance of fine lines, firmness, and texture typically become more noticeable after several weeks of consistent daily use, though results vary by individual.
Is Coenzyme Q10 better than retinol? They serve different purposes: retinol helps accelerate skin renewal, while Coenzyme Q10 primarily provides antioxidant protection and supports healthier-looking skin. Many routines successfully include both.
Is this serum suitable for sensitive skin? Yes, it is fragrance-free and formulated with hydrating, skin-supporting ingredients that many people with sensitive skin tolerate well. A patch test is recommended before full application, especially for highly reactive skin.
Is the Timeless Coenzyme Q10 Serum good, according to reviews? With over 3,200 reviews and a 4.9-star average, customers consistently praise its gentle, non-sticky feel and the improvements to their skin's glow and texture.
What is a good antioxidant serum for the face? This serum delivers 2% Coenzyme Q10 (Ubiquinone) for antioxidant protection alongside 8% Matrixyl® 3000 peptides and 1% Hyaluronic Acid, in a fragrance-free, vegan formula made in the USA.
Where can I buy Timeless skincare products in Canada, Australia, or South Africa? Timeless offers worldwide shipping, so the Coenzyme Q10 Serum can be ordered directly from timelessha.com outside the U.S. as well.
What customers say
Rated 4.9 out of 5 stars from 3,243 reviews.
"I've been using this for over 10 years now. Everybody says that my skin looks very young and healthy." — Denise S., Verified Buyer (Age 60+)
"My skin has never looked better… better than more expensive options… not… sticky — just juicy goodness." — Jennifer R., Verified Buyer
"Have seen a drastic change in my skin's glow and texture since starting this in combo with the vitamin c serum. Love it!" — Kristin
Protects skin cells against damage from free radicals
Stimulates production of healthy skin cells
As we age, our skin's metabolism slows down, resulting in a rougher texture, thinning skin, and visible lines and wrinkles becoming more pronounced. Coenzyme Q10 is found in abundance in young skin but decreases significantly over time, as our body does not produce it at the same rate.
Our Coenzyme Q10 Serum has a 2% concentration that boosts energy in skin cells to build back that lost collagen and elastin for firmer, smoother skin, and an overall refreshed appearance. 8% concentration of Matrixyl® 3000 helps to increase collagen synthesis by up to 258% and is used as a safe and effective alternative to Retinoids. 1% concentration of Hyaluronic Acid provides powerful hydration that soothes and smooths skin texture.
APPLICATION: Apply 2-3 drops onto fingers and spread the serum evenly over desired area. Wait until the product has fully absorbed into the skin before the next step in your routine.
FREQUENCY: Use Daily, AM or PM (recommended)
Effective for 24 months from the date of manufacture.
The Defender - Our Coenzyme Q10 Serum is made with three wrinkle-fighting superstar ingredients, Ubiquinone, Matrixyl® 3000 and 100% Pure Hyaluronic Acid, and is the ultimate defense against the visible signs of aging. Coenzyme Q10 is a powerful, naturally-occurring antioxidant that energizes skin cells to rebuild collagen and elastin. Matrixyl® 3000, a safe alternative to Retinoids and Retinols, maximizes the synthesis of collagen in the skin, while Hyaluronic Acid increases and retains moisture for skin that looks and feels hydrated. This anti-aging trifecta works overtime to replenish and repair while smoothing fine lines & wrinkles.
Recommended for: All skin types, especially those with visible signs of aging. Not recommended for anyone with Vitiligo skin condition
Targets: Visible signs of aging, Wrinkles, Dullness, Hyperpigmentation, Discoloration
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Benefits
How it works
Directions
Shelf Life
Ingredients
Powerful antioxidant defense
Minimizes visible signs of aging
Helps restore skin's firmness & texture
Repairs damaged skin
Protects skin cells against damage from free radicals
Stimulates production of healthy skin cells
As we age, our skin's metabolism slows down, resulting in a rougher texture, thinning skin, and visible lines and wrinkles becoming more pronounced. Coenzyme Q10 is found in abundance in young skin but decreases significantly over time, as our body does not produce it at the same rate.
Our Coenzyme Q10 Serum has a 2% concentration that boosts energy in skin cells to build back that lost collagen and elastin for firmer, smoother skin, and an overall refreshed appearance. 8% concentration of Matrixyl® 3000 helps to increase collagen synthesis by up to 258% and is used as a safe and effective alternative to Retinoids. 1% concentration of Hyaluronic Acid provides powerful hydration that soothes and smooths skin texture.
APPLICATION: Apply 2-3 drops onto fingers and spread the serum evenly over desired area. Wait until the product has fully absorbed into the skin before the next step in your routine.
FREQUENCY: Use Daily, AM or PM (recommended)
Effective for 24 months from the date of manufacture.
Benefits
Powerful antioxidant defense
Minimizes visible signs of aging
Helps restore skin's firmness & texture
Repairs damaged skin
Protects skin cells against damage from free radicals
Stimulates production of healthy skin cells
How it works
As we age, our skin's metabolism slows down, resulting in a rougher texture, thinning skin, and visible lines and wrinkles becoming more pronounced. Coenzyme Q10 is found in abundance in young skin but decreases significantly over time, as our body does not produce it at the same rate.
Our Coenzyme Q10 Serum has a 2% concentration that boosts energy in skin cells to build back that lost collagen and elastin for firmer, smoother skin, and an overall refreshed appearance. 8% concentration of Matrixyl® 3000 helps to increase collagen synthesis by up to 258% and is used as a safe and effective alternative to Retinoids. 1% concentration of Hyaluronic Acid provides powerful hydration that soothes and smooths skin texture.
Directions
APPLICATION: Apply 2-3 drops onto fingers and spread the serum evenly over desired area. Wait until the product has fully absorbed into the skin before the next step in your routine.
*Based on a clinical trial of 20 participants ages 32-64, after 3 weeks of use. Performed by a third party.
100%
agree skin feels more moisturized and regenerated
100%
agree skin firmness and elasticity is improved
100%
agree wrinkles are visibly reduced
FAQs
What is the shelf life of the Coenzyme Q10 Serum?
For best results, we recommend using your Coenzyme Q10 Serum within 24 months of receipt.
For further guidance and customer consideration, the period after opening symbol is provided on the product box. Use upon receipt and refrigeration is suggested to assist with the shelf life of the product.
How long does the Coenzyme Q10 Serum last with daily use?
With the suggested daily use amount of 2-3 drops, a 1oz bottle of Coenzyme Q10 Serum typically lasts about 1 month.
Can I use the Coenzyme Q10 Serum under the eyes?
We do not recommend applying the Coenzyme Q10 Serum directly to the under-eye area. The skin around the eyes is very delicate, therefore, we recommend using products specifically formulated for eye area instead.
How do I layer the Coenzyme Q10 Serum with my other Timeless products?
As a general rule, apply products from thinnest to thickest. For further assistance with the Coenzyme Q10 Serum in your Timeless routine, we welcome you to email consult@timelessha.com!
Is the Coenzyme Q10 Serum safe for use during pregnancy?
Yes it is suitable for use during pregnancy and breastfeeding when used as directed. Review the ingredient list of the 20% Vitamin C + E Ferulic Acid Serum and consult your healthcare provider if needed. For external use on face and neck only. Avoid eyes and chest/nipple area. Discontinue if irritation occurs. Store in a cool, dry place away from sunlight.
What is the difference between the Coenzyme Q10 Serum & Matrixyl® 3000 Serum?
While both have similar results each is uniquely different. Coenzyme Q10 is a powerful antioxidant combined with anti-aging polypeptide, while the Matrixyl 3000 is a polypeptide-only formulation for those who have another antioxidant choice or can not use the Ubiquinone ingredient (found in the Coenzyme Q10). Alternate use of the two serums or choose one best suited for your specific skin care needs.
For further assistance with the Coenzyme Q10 Serum in your Timeless routine, we welcome you to email consult@timelessha.com!
Why is the Coenzyme Q10 Serum not recommended for people with vitiligo?
Coenzyme Q10 may support skin-brightening effects in some users. Because vitiligo involves areas of hypopigmentation, we recommend avoiding use or using caution, as uneven tone may become more noticeable.
If you have vitiligo, we suggest consulting your dermatologist before adding the Coenzyme Q10 Serum to your routine.
What is the Coenzyme Q10 Serum used for?
The Coenzyme Q10 Serum is designed to help reduce the appearance of fine lines, wrinkles, and other visible signs of aging. It combines 2% Coenzyme Q10 (Ubiquinone), Matrixyl® 3000 peptides, Hyaluronic Acid, and Vitamin E to support firmer-looking, smoother, and more hydrated skin while helping defend against environmental stressors and free radical damage.
What does Coenzyme Q10 do for your skin?
Coenzyme Q10 is a naturally occurring antioxidant found in the body that helps protect skin from oxidative stress caused by UV exposure and pollution. Because natural CoQ10 levels decline with age, topical application can help support healthier-looking skin, improve the appearance of firmness, and minimize visible signs of aging.
Can I use Coenzyme Q10 Serum every day?
Yes. The Coenzyme Q10 Serum is gentle enough for daily use and can be applied morning or evening after cleansing. Consistent use helps maintain hydration while Matrixyl® 3000 peptides improves the appearance of skin texture and firmness over time.
Should I use Coenzyme Q10 Serum in the morning or at night?
You can use the Coenzyme Q10 Serum in either your morning or evening skincare routine. Its antioxidant, hydrating, and Matrixyl® 3000 peptide-rich formula help support healthy-looking skin throughout the day and overnight. It provides continuous nourishment and antioxidant support.
Can I use Coenzyme Q10 Serum with Vitamin C?
Yes. Coenzyme Q10 pairs well with Vitamin C. Vitamin C helps brighten the appearance of skin and provides antioxidant protection, while Coenzyme Q10 helps defend against oxidative stress and supports smoother-looking skin. Together they create a comprehensive antioxidant skincare routine.
Can I use Coenzyme Q10 Serum with retinol?
Yes. The Coenzyme Q10 Serum with Matrixyl® 3000 peptides complements retinol by helping replenish hydration and providing antioxidant support. Apply our Coenzyme Q10 serum before your moisturizer, and if you're using retinol at night, follow your preferred layering routine.
Is Timeless Coenzyme Q10 Serum good for mature skin?
Yes. Mature skin naturally produces less Coenzyme Q10 over time. This serum replenishes topical antioxidant support while Matrixyl® 3000 peptides and Hyaluronic Acid help improve the appearance of firmness, hydration, and visible wrinkles, making it an excellent addition to mature skincare routines.
Does Coenzyme Q10 help with wrinkles?
Coenzyme Q10 helps reduce oxidative stress that contributes to visible skin aging. Combined with Matrixyl® 3000 peptides, it helps soften the appearance of fine lines and wrinkles while promoting smoother, healthier-looking skin.
Can I use Coenzyme Q10 Serum with Hyaluronic Acid?
Yes. The Coenzyme Q10 Serum already contains Hyaluronic Acid, which helps attract and retain moisture for hydrated, plumper-looking skin. This built-in hydration complements the antioxidant and Matrixyl® 3000 peptides benefits in a single formula.
Is Timeless Coenzyme Q10 Serum fragrance-free?
Yes. The Coenzyme Q10 Serum is formulated without added fragrance, making it a great option for those who prefer fragrance-free skincare.
How long does it take to see results from Coenzyme Q10 Serum?
Hydration can often be noticed after the first few applications. Improvements in the appearance of fine lines, firmness, and overall skin texture typically become more noticeable after several weeks of consistent daily use, although results vary by individual.
What makes Timeless Skin Care Coenzyme Q10 Serum different from other CoQ10 serums?
Timeless Skin Care Coenzyme Q10 Serum combines 2% Coenzyme Q10 with 8% Matrixyl® 3000 peptides, 1% Hyaluronic Acid, and Vitamin E in a lightweight, fragrance-free formula. Instead of relying on a single antioxidant, it provides hydration, peptide support, and antioxidant protection in one daily serum.
Is Coenzyme Q10 better than retinol?
They serve different purposes. Retinol helps accelerate skin renewal, while Coenzyme Q10 primarily provides antioxidant protection and supports healthier-looking skin. Many skincare routines successfully include both, using Coenzyme Q10 to complement retinol by helping maintain hydration and supporting the skin barrier.
Is Timeless Skin Care Coenzyme Q10 Serum suitable for sensitive skin?
The Coenzyme Q10 Serum is fragrance-free and formulated with hydrating and skin-supporting ingredients that many people with sensitive skin tolerate well. As with any new skincare product, it's recommended to perform a patch test before full application, especially if your skin is highly reactive.
Why does Coenzyme Q10 become more important as you age?
Natural Coenzyme Q10 levels decline over time, making skin more susceptible to oxidative stress from sun exposure and pollution. Topical Coenzyme Q10 helps replenish antioxidant support, contributing to smoother, firmer, and healthier-looking skin.
I’ve been using this for over 10 years now. Everybody says that my skin looks very young and healthy. I will continue using this product.
Monica W.
Verified Buyer
Reviewing
Coenzyme Q10 Serum
I recommend this product
Age 45-60
Rated 5 out of 5 stars
5/10/26
Unexpected surprise!
I love how this makes my skin feel.
Jennifer R.
Verified Buyer
Reviewing
Coenzyme Q10 Serum
I recommend this product
Age 45-60
Rated 5 out of 5 stars
5/8/26
My go-to morning serum
Every morning, I use a few pumps of the Timeless Skin Care Vitamin C Serum, and then I follow up with this Coenzyme Q10 Serum to lock in the moisture. My skin has never looked better. It’s a great product, better than more expensive options, in my opinion. It’s not the least bit sticky - just juicy goodness. Give it a try!
Kristin
Reviewing
Coenzyme Q10 Serum
I recommend this product
Rated 5 out of 5 stars
5/6/26
5 Stars
Have seen a drastic change in my skins glow and texture since starting this in combo with the vitamin c serum.
Love it!
Kathryn L.
Verified Buyer
Reviewing
Coenzyme Q10 Serum
I recommend this product
Age 60+
Rated 5 out of 5 stars
4/1/26
Great serum
Love this serum! Have noticed an overall appearance of the way my skin looks. Skin texture is smoother & lines less visible.
